Material from this article can be used in other publications Analysis of microbial genomes has contributed to the development of new antibiotics, diagnostic tools, vaccines, medical treatments, and environmental cleanup techniques. provided that the correct acknowledgement is given with the reproduced material A variety of organic chemicals can be synthesised at large scale with the help of genetically engineered microorganisms. Perspectives of genetically engineered microbes for groundwater bioremediation Dick B. Janssen *a and Gerhard Stucki b Biodegradation is the main process for the removal of organic compounds from the environment, but proceeds slowly for many synthetic chemicals of environmental concern. The extent of horizontal gene transfer from GEMs in the environment, compared to that of native organisms including benefits regarding bacterial bioremediation that may occur as a result of such transfer, is discussed. Tel: +31-50-363-4008, b Applications of Genetically Engineered Products that Involve Microbes. d.b.janssen@rug.nl These advancements in microbiology have changed the course of history and greatly improved the quality of life for many people around the world. Application to Industries: Genetically designed bacteria are put into use for generating industrial chemicals. Summarize the advantages of genetically engineered pharmaceutical products; Advances in molecular biology have led to the creation of entirely new fields of science. Please enable JavaScript Perspectives of genetically engineered microbes for groundwater bioremediation ... no full-scale applications have emerged. Genetic engineering involves the use of in vitro techniques in the isolation, manipulation, alteration, and expression of DNA or RNA and in the development of genetically engineered microbes (Madigan et al., 2012). Fetching data from CrossRef. Registered in England & Wales No. The important aspects of using GEMs in bioremediation, such as development of novel strains with desirable properties through pathway construction and the modification of enzyme specificity and affinity, are discussed in detail. Reproduced material should be attributed as follows: Information about reproducing material from RSC articles with different licences Learn vocabulary, terms, and more with flashcards, games, and other study tools. This paper presents a critical review of the literature on the application of genetically engineered microorganisms (GEMs) in bioremediation. This article is licensed under a Creative Commons Attribution-NonCommercial The specific characteristic of open biotechnological applications has clearly necessitated the development of Gallery. Register to receive personalised research and resources by email, Use of Genetically Engineered Microorganisms (GEMs) for the Bioremediation of Contaminants, Department of Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL, USA, Department of Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, IL, USA, /doi/full/10.1080/07388550600842794?needAccess=true. The major technical and scientific issues are illustrated by comparing two examples, that of 1,2-dichloroethane where successful full-scale application of pump-and-treat biotreatment processes has been achieved, and 1,2,3-trichloropropane, for which protein and genetic engineering yielded effective bacterial cultures that still await application. These GEM have higher degradative capacity and have been demonstrated successfully for the degradation of various pollutants under defined conditions. In this chapter, we describe various techniques for the development of genetically modified microorganisms along with different examples of recombinant produced.