zocor side effects

40. JAMA 283 (2000): 3205-10, 14. In a 48-week, controlled study in adolescent boys and girls who were at least 1 year post-menarche, 10-17 years of age (43.4% female, 97.7% Caucasians, 1.7% Hispanics, 0.6% Multiracial) with heterozygous familial hypercholesterolemia (n=175), treated with placebo or Zocor (10-40 mg daily), the most common adverse reactions observed in both groups were upper respiratory infection, headache, abdominal pain, and nausea. "Product Information. March 02, 2017. Are Statin Side Effects 'All in Your Head'? Sundram F, Roberts P, Kennedy B, Pavord S "Thrombotic thrombocytopenic purpura associated with statin treatment." Ann Intern Med 137 (2002): 617-8, 27. Learn cholesterol basics, drug classes, and available drugs along... Do you know the different cholesterol levels and what they mean? Feldmann R, Mainetti C, Saurat JH "Skin lesions due to treatment with simvastatin (Zocor)." High cholesterol treatment includes lifestyle changes (diet and exercise), and medications such as statins, bile acid resins, and fibric acid derivatives. Available from: URL: http://www.tga.gov.au/adr/aadrb/aadr0612.htm." Cerner Multum, Inc. "UK Summary of Product Characteristics." In patients with coronary heart disease, diabetes, peripheral vascular disease, or history of stroke or other cerebrovascular disease, simvastatin is prescribed for reducing the risk of mortality by reducing death from coronary heart disease, reducing nonfatal myocardial infarction (heart attack) and stroke, and reducing the need for coronary and noncoronary revascularization procedures. Alvarez JM, Rawdanowiz TJ, Goldstein J "Rhadbdomyolysis after coronary artery bypass grafting in a patient receiving simvastatin." The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine. other cardiovascular diseases. The incidence of myopathy/rhabdomyolysis was <0.1% in patients treated with Zocor. In rare cases, Zocor can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to … The most common side effects of simvastatin are: Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Last updated on Mar 4, 2020. Table 2: Adverse Reactions Reported Regardless of Causality by ≥2% of Patients Treated with Zocor and Greater than Placebo in 4S. Zocor has been studied extensively in clinical trials, with more than 21,000 people having been evaluated. Joe Graedon-March 02, 2017-41 Comments “I was placed on statin medication in 2004. With therapy discontinuation or interruption, transaminase levels generally returned to pretreatment levels. Walker JF "Simvastatin: the clinical profile." JAMA 292 (2004): 2585-90, 13. Zocor (simvastatin) side effects list for healthcare professionals. Many people using this medication do not have serious side effects. blood vessels in the body, which protects you against heart attack, stroke, and Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem." Rudski L, Rabinovitch MA, Danoff D "Systemic immune reactions to HMG-CoA reductase inhibitors - Report of 4 cases and review of the literature." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The more commonly reported adverse effects have included upper respiratory infection, headache, abdominal pain, constipation, and nausea. Neurology 58 (2002): 1333-7, 48. Common side effects of Zocor include: heartburn, gas, bloating, stomach pain, indigestion, nausea, constipation, diarrhea, headache, joint pain, muscle pain, skin rash, sleep problems (insomnia), mild memory problems or confusion, or ; cold symptoms such as stuffy nose, sneezing, or sore throat. Side effects reported by some people include muscle pain and digestive problems. Serious side effects and their symptoms can include: Liver problems, such as elevated levels of liver enzymes (proteins). Lancet 341 (1993): 114. Along with its needed effects, simvastatin (the active ingredient contained in Zocor) may cause some unwanted effects. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." These side effects include nausea, dizziness, and vomiting. levels of the "good," or HDL cholesterol, may protect against narrowing of the How Do I Lower My Cholesterol (Triglycerides). rhabdomyolysis. Duits N, Bos FM "Depressive symptoms and cholesterol-lowering drugs." The difference between the two are that high Joe Graedon. Applies to simvastatin: oral suspension, oral tablet. Ann Pharmacother 36 (2002): 820-3, 26. Finsterer J, Zuntner G "Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion." Zocor can cause mild or serious side effects. greater risk of stroke, heart attack, and cardiovascular diseases, some of which The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased during the subsequent years of treatment. Drugs 50 (1995): 334-63, 5. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients, Statins Going Generic Saved Medicare Billions, We comply with the HONcode standard for trustworthy health information -. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. Dermatology 186 (1993): 272, 54. HDL (high-density lipoprotein), or the "good" cholesterol, and LDL The most serious potential side effects are liver damage and muscle inflammation or Pregnant women should not use Zocor because the developing fetus requires cholesterol for development, and Zocor reduces the production of cholesterol. Lancet 353 (1999): 1763-4, 38. HDL and LDL combined, is J Intern Med 240 (1996): 403-4, 18. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia." Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy." Johnson JL, Loomis IB "A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis." BMJ 332 (2006): 950, 49. Bannwarth B, Miremont G, Papapietro PM "Lupuslike syndrome associated with simvastatin."