2005 Mar;11(2):81-4. doi: 10.1016/j.parkreldis.2004.07.012. Statin therapy continues to help men lower their cholesterol levels, which can reduce their risk for heart attack or stroke. 2013 Dec;14(17):2449-51. doi: 10.1517/14656566.2013.834630. HHS NLM 2019 Jul;33(7):685-694. doi: 10.1007/s40263-019-00633-3. CNS Drugs. NIH Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions. For example, people with depression may have low cholesterol levels, but it has not been proved that lowering cholesterol with statin therapy causes depression. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. The safety and effectiveness of statins as treatment for HIV-dyslipidemia: the evidence so far and the future challenges. Renshaw PF, Parsegian A, Yang CK, Novero A, Yoon SJ, Lyoo IK, Cohen BM, Carlezon WA Jr. Pharmacol Biochem Behav. Of the individual statins, simvastatin, by far the most widely used agent, was associated with a 7% reduction in the risk of developing depression, whereas atorvastatin was associated with an 11% increase in the risk of developing depression. Pharmacol Biochem Behav. However, the benefits of lowering total and LDL cholesterol have been demonstrated extensively, particularly in individuals with heart disease or at high risk of heart disease or strokes. Lieberman A, Lyons K, Levine J, Myerburg R. Parkinsonism Relat Disord. 2019;26:e000. CNS Drugs. 2012 Sep;13(13):1901-9. doi: 10.1517/14656566.2012.706604. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. Eur J Cardiovasc Nurs. Depression is a common malady associated with numerous chronic medical conditions such as coronary artery disease, hypertension, and diabetes. Diagnosis and management of statin intolerance. Preparation of this article included an extensive literature search of statins and depression using PubMed from 1972 to 2012. Areas covered: This article reviews i) cholesterol function in the brain, ii) how low cholesterol can cause depression, iii) a brief introduction of the serotonin system and how low cholesterol can disturb it, iv) neurosteroids and how they may lead to depression, and v) some direct evidence that statins can cause depression as well as contradicting evidence. Comment on: the relationship between statins and depression: a review of the literature. Köhler-Forsberg O, Gasse C, Berk M, Østergaard SD. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Nature Reviews Cardiology. Schang L, Koller D, Franke S, Sundmacher L. BMJ Open. 2018;19(8):674-687. doi: 10.2174/1389200219666180305143501. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Alonso R, et al. doi: 10.1136/bmjopen-2019-030272. Introduction: Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. Introduction: This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! 2018;12:757. Statin medications also reduce inflammation. | Epub 2006 Nov 13. Get the latest research from NIH: https://www.nih.gov/coronavirus. Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. Epub 2008 Nov 5. 2014 Sep;124:174-9. doi: 10.1016/j.pbb.2014.06.006. Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. USA.gov. Clipboard, Search History, and several other advanced features are temporarily unavailable. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. Epub 2012 Jul 7. 2009 Mar;92(1):88-92. doi: 10.1016/j.pbb.2008.10.017. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. Adverse effects of statin therapy: Perception vs. the evidence — focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. | Since antidepressants work by changing neurotransmitter levels in the brain, it's possible for the chemicals to become imbalanced, which can lead to more severe mood symptoms, including thoughts of suicide. Please enable it to take advantage of the complete set of features! Med Hypotheses. Clipboard, Search History, and several other advanced features are temporarily unavailable. However, confounding data also exist refuting a positive effect of these drugs at elevating mood. Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study. Expert Opin Pharmacother. CNS Drugs. Zuzarte P, Duong A, Figueira ML, Costa-Vitali A, Scola G. Curr Drug Metab. © Copyright 2018 Physicians Postgraduate Press, Inc. NLM Molero Y, Cipriani A, Larsson H, Lichtenstein P, D'Onofrio BM, Fazel S. Lancet Psychiatry. 2007;68(6):1296-9. doi: 10.1016/j.mehy.2006.09.043. Mach F, et al. USA.gov. | Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats. | Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. Köhler-Forsberg O, Gasse C, Berk M, Østergaard SD. 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Am J Cardiovasc Drugs. Conclusions: These results suggest that the association between statin treatment and antidepressant use is unspecific (equivalent association between statins and most other drugs) and that the association between statin use and depression diagnoses is mediated by residual confounding, bias or by downstream effects of the statin prescription (seeing a physician more often). Statins, cholesterol, Co-enzyme Q10, and Parkinson's disease. eCollection 2019. Depression and Statin Drug Use From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds. Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease. Journal of Atherosclerosis and Thrombosis. 2012 Mar;11(1):85-96. doi: 10.1016/j.ejcnurse.2010.08.008. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. Exploring the role of hospitals and office-based physicians in timely provision of statins following acute myocardial infarction: a secondary analysis of a nationwide cohort using cross-classified multilevel models. Kelly RR, McDonald LT, Jensen NR, Sidles SJ, LaRue AC. Get the latest public health information from CDC: https://www.coronavirus.gov. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. This site needs JavaScript to work properly. COVID-19 is an emerging, rapidly evolving situation. Expert Opin Pharmacother. Front Psychiatry. There is evidence suggesting an antidepressant effect when statins are adjunctively co-prescribed with antidepressant medicines. Epub 2014 Jun 12. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.