Here we present the mechanisms of statin intolerance … She covers common issues such as symptom management, medication choices, titration of meds, monitoring patients on statins… Although many patients report statin-related muscle symptoms, studies indicate that the majority of these patients can tolerate a statin … myalgia without a significantly raised CK, then a change of statin might allow satisfactory control of lipid levels without a recurrence of intolerance if a patient has muscle related side effects then a water-soluble (hydrophilic) statin … if mild side effect e.g. Lipid Management for Patients with Statin Intolerance Richard Clarens, PharmD UND School of Medicine & Health Sciences Department of Family & Community Medicine Altru Family Medicine Residency OBJECTIVES • Review current guidelines of lipid management for dyslipidemia • Define and identify patients who are statin intolerant. Statin intolerance is a commonly encountered clinical problem for which useful management strategies exist. The following are key points to remember from a systematic review for management of patients with dyslipidemia: Although statins are a mainstay of treatment for patients with dyslipidemia who are at risk for cardiovascular disease (CVD), a substantial subset of patients become intolerant to statins … Therefore, in patients who are deemed “statin-intolerant,” lifestyle changes and alternative classes of drugs should be pursued to achieve LDL-C target levels and minimize risk. Host: Betsy Stovsky RN, MSN Dr. Leslie Cho, Section Head, Preventive Cardiology and Rehabilitation and Director of Women’s Cardiovascular Center discusses tips for health care providers in treating statin intolerance.