All of the studies had a placebo run-in followed by a randomized, double-blind, active treatment phase of at least 4 weeks with a statin. We conclude that all statins are effective in decreasing triglyceride levels, but only in hypertriglyceridemic patients. La Fountaine MF, Cirnigliaro CM, Hobson JC, Lombard AT, Specht AF, Dyson-Hudson TA, Bauman WA. Since statins lower TG by endocytosing TG-rich apoB particles, the TG themselves are simply re-compartmentalized by going from plasma into the liver. We then assessed the effect of various statins on triglycerides using a pooled laboratory database of 2,689 subjects who had participated in 7 separate studies with similar designs. Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects. Reduces triglycerides and raises HDL more than Zocor. Statins and Triglycerides. Get the latest research from NIH: https://www.nih.gov/coronavirus. Cons: one of the least-studied statins, meaning there's less evidence that its cholesterol-lowering benefits translate into a lower risk … | Alexopoulos AS, Qamar A, Hutchins K, Crowley MJ, Batch BC, Guyton JR. Curr Diab Rep. 2019 Feb 26;19(4):13. doi: 10.1007/s11892-019-1136-3. Due to the relatively constant triglyceride/LDL cholesterol ratio, our analysis indicates that the more effective the statin is in decreasing LDL cholesterol, the more effective it will also be in decreasing triglyceride levels in patients with hypertriglyceridemia. Am J Cardiol. Triglycerides: Emerging Targets in Diabetes Care? Table I displays the triglyceride and LDL cholesterol reductions and triglyceride/LDL cholesterol ratio for the studies by Bakker-Arkema and coworkers and Stein et al. Statin Dose Comparison The chart below shows statin doses expected to provide similar LDL reduction. For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low density lipoprotein cholesterol: The triglyceride/LDL cholesterol ratio was initially applied to several published studies, and found to be approximately 1.0 and 0.5 in hypertriglyceridemic and nonhypertriglyceridemic populations, respectively. STATIN CONVERSION CHART % LDL Reduction Simvastatin (Zocor) Atorvastatin (Lipitor) Rosuvastatin (Crestor) Fluvastatin (Lescol) Lovastatin (Mevacor) Pravastatin (Pravachol) Ezetimibe/Simvastatin … In response to these findings, we conducted comparative assessments to determine whether all statins are effective in lowering triglyceride levels and whether their effect on triglycerides is related to factors such as drug, dose, and baseline triglyceride levels. All of the studies had a placebo run-in followed by a randomized, double-blind, active treatment phase of at least 4 weeks with a statin. Effect of Lipid-Testing Interval on Stoke Risk among Newly Diagnosed Dyslipidemia Patients Initiated on Statins. The Centers for Disease Control and Prevention lists cardiovascular-related diseases as a leading cause of mortality.1 The medication class of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, more commonly known as statins… Statins They lower LDL and triglycerides and can slightly raise HDL. Causes and Consequences of Hypertriglyceridemia. We conclude that all statins are effective in decreasing triglyceride levels, but only in hypertriglyceridemic patients. The lower the better? When you get your cholesterol levels tested, most doctors also test triglyceride levels, since high levels of these fats also increase your risk for heart disease. In 1996, the first 2 studies using 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor ("statin") therapy in hypertriglyceridemic subjects were published. Get the latest public health information from CDC: https://www.coronavirus.gov. Entry into these studies required a triglyceride level of <400 mg/dL. 2003 Dec 11;145(50):46-9. [LDL cholesterol in normal range. Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia. In subjects with baseline triglyceride >250 mg/dL, significant and dose-dependent reductions in triglyceride of 22-45% were seen with all statins. Appendix A: Grouping of statins. Endocr Rev. 2019 Apr 1;40(2):537-557. doi: 10.1210/er.2018-00184. Am J Cardiol. We use cookies to help provide and enhance our service and tailor content and ads. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The major long-term clinical event trials limited entry to subjects with triglycerides … Fenofibrate therapy to lower serum triglyceride concentrations in persons with spinal cord injury: A preliminary analysis of its safety profile. Copyright © 2020 Elsevier B.V. or its licensors or contributors. COVID-19 is an emerging, rapidly evolving situation. This site needs JavaScript to work properly. The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk. Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. To standardize these assessments, we devised a ratio that related changes in triglyceride levels to the known predictable response of low-density lipoprotein (LDL) cholesterol to statins. 2004 Jan 1;93(1):31-9. doi: 10.1016/j.amjcard.2003.09.008. There are other ways to lower TG. The triglyceride/LDL cholesterol ratio was evaluated using a linear model that included baseline triglyceride level, drug, and dose. This triglyceride/LDL cholesterol ratio was obtained by dividing the percent change from baseline in the triglyceride level by the percent change from baseline in the LDL cholesterol level. Am J Cardiol. Bakker-Arkema RG, Davidson MH, Goldstein RJ, Davignon J, Isaacsohn JL, Weiss SR, Keilson LM, Brown WV, Miller VT, Shurzinske LJ, Black DM. Due to the relatively constant triglyceride/LDL cholesterol ratio, our analysis indicates that the more effective the statin is in decreasing LDL cholesterol, the more effective it will also be in decreasing triglyceride levels in patients with hypertriglyceridemia. The triglyceride/LDL cholesterol ratio was evaluated using a linear model that included baseline triglyceride level, drug, and dose. To standardize these assessments, we devised a ratio that related changes in triglyceride levels to the known predictable response of low-density lipoprotein (LDL) cholesterol to statins. 2019 May 24;8(5):742. doi: 10.3390/jcm8050742. Clipboard, Search History, and several other advanced features are temporarily unavailable. Entry into these studies required a triglyceride level of <400 mg/dL. NIH Schaefer EJ, McNamara JR, Tayler T, Daly JA, Gleason JL, Seman LJ, Ferrari A, Rubenstein JJ.